Modafinil may not be a suitable
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This Central Nervous System (CNS) stimulant is prescribed
for narcolepsy, and prevents sufferers from falling
asleep during
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MODAFINIL
Generic Name: modafinil (moe DA fih nill)
Brand Names: Provigil
What is the most important information I should know about
modafinil?
• Use caution when driving, operating machinery, or performing other hazardous
activities. Modafinil may affect your judgment, thinking, or motor skills. If
you experience any of these effects, avoid hazardous activities.
• It is best to avoid alcohol while taking modafinil. Alcohol or modafinil
may have altered effects if taken together.
• Modafinil may decrease the effects of hormonal methods of birth control
including birth control pills and depot and implantable formulations (e.g., Norplant,
Depo-Provera). Use a second, nonhormonal form of birth control while taking modafinil,
and for one month after stopping modafinil, if prevention of pregnancy is desired.
• Modafinil may be habit forming. You should discuss the abuse and dependence
potential of modafinil with your doctor. Do not stop taking modafinil without
first talking to your doctor. Your doctor may want to gradually lower the dose
of the medication before stopping treatment.
What is modafinil?
• The exact way that modafinil works is not known.
• Modafinil is used to improve wakefulness in patients with excessive daytime
sleepiness associated with narcolepsy, obstructive sleep apnea/ hypoapnea syndrome
(OSAHS), and shift work sleep disorder (SWSD).
• Modafinil may also be used for purposes other than those listed in this
medication guide.
What should I discuss with my healthcare provider before taking
modafinil?
• Before taking modafinil, tell your doctor if you have
· left ventricular hypertrophy (enlarged left heart ventricle);
· chest pain, irregular heartbeats, or other symptoms of mitral valve
prolapse due to central nervous system stimulant use;
· a recent history of a heart attack;
· high blood pressure;
· angina (chest pain);
· abused medicines called stimulants or street drugs;
· a history of mental illness;
· kidney disease; or
· liver disease.
• You may not be able to take modafinil, or you may require a dosage adjustment
or special monitoring during treatment if you have any of the conditions listed
above.
• Modafinil is in the FDA pregnancy category C. This means that it is not
known whether it will be harmful to an unborn baby. Do not take modafinil without
first talking to your doctor if you are pregnant or could become pregnant during
treatment.
• It is not known whether modafinil passes into breast milk. Do not take
modafinil without first talking to your doctor if you are breast-feeding.
• If you are older than 65 years of age, you may be more likely to experience
side effects from modafinil. You may require a lower dose or special monitoring
during treatment.
How should I take modafinil?
• Take modafinil exactly as directed by your doctor. If you do not understand
these directions, ask your pharmacist, nurse, or doctor to explain them to you.
• Take each dose with a full glass of water.
• Modafinil can be taken with or without food.
• Modafinil is usually taken once a day. Follow your doctor's instructions.
• It is important to take modafinil regularly to get the most benefit.
• Modafinil is not a replacement for sleep. Modafinil may reduce the signs
of sleepiness, but may not completely treat this problem. Some drowsiness may
continue. Potentially hazardous activities such as driving or operating machinery
should only be performed if the level of wakefulness achieved is sufficient to
permit such activities.
• Other treatments such as CPAP (continuous positive airway pressure) use
should be continued as directed by your doctor if you have obstructive sleep
apnea/ hypoapnea syndrome (OSAHS) and are taking modafinil.
• Modafinil may be habit forming. You should discuss the abuse and dependence
potential of modafinil with your doctor. Do not stop taking modafinil without
first talking to your doctor. Your doctor may want to gradually lower the dose
of the medication before stopping treatment.
• Store modafinil at room temperature away from moisture and heat.
What happens if I miss a dose?
• Take the missed dose as soon as you remember as directed by your doctor.
A missed dose taken late in the waking day may cause insomnia. If you don't remember
until it is almost time for the next dose, skip the missed dose and take only
the next regularly scheduled dose. Do not take a double dose of this medication
unless otherwise directed by your doctor.
What happens if I overdose?
• Seek emergency medical attention if an overdose is suspected.
• Symptoms of a modafinil overdose may include excitation, agitation, insomnia,
sleep disturbances, anxiety, irritability, aggressiveness, confusion, nervousness,
tremor, palpitations, nausea, and diarrhea.
What should I avoid while taking modafinil?
• Use caution when driving, operating machinery, or performing other hazardous
activities. Modafinil may affect your judgment, thinking, or motor skills. If
you experience any of these effects, avoid hazardous activities.
• It is best to avoid alcohol while taking modafinil. Alcohol or modafinil
may have altered effects if taken together.
• Modafinil may decrease the effects of hormonal methods of birth control
including birth control pills and depot and implantable formulations (e.g., Norplant,
Depo-Provera). Use a second, nonhormonal form of birth control while taking modafinil,
and for one month after stopping modafinil, if prevention of pregnancy is desired.
What are the possible side effects of modafinil?
• If you experience any of the following uncommon but serious side effects,
stop taking modafinil and seek emergency medical attention or contact your doctor
immediately:
· an allergic reaction (difficulty breathing; closing of the throat; swelling
of the lips, tongue, or face; or hives);
· irregular heartbeats;
· low or high blood pressure; or
· shortness of breath.
• Other, less serious side effects may be more likely to occur. Continue
to take modafinil and talk to your doctor if you experience
· headache;
· infection;
· nausea, decreased appetite, or diarrhea;
· chills;
· dry mouth;
· runny nose;
· sore throat;
· nervousness;
· anxiety;
· dizziness;
· insomnia;
· depression; or
· numbness or tingling.
• Modafinil may be habit forming. You should discuss the abuse and dependence
potential of modafinil with your doctor. Do not stop taking modafinil without
first talking to your doctor. Your doctor may want to gradually lower the dose
of the medication before stopping treatment.
• Side effects other than those listed here may also occur. Talk to your
doctor about any side effect that seems unusual or that is especially bothersome.
What other drugs will affect modafinil?
• Modafinil may decrease the effects of hormonal methods of birth control
including birth control pills and depot and implantable formulations (e.g., Norplant,
Depo-Provera). Use a second, nonhormonal form of birth control while taking modafinil,
and for one month after stopping modafinil, if prevention of pregnancy is desired.
• Before taking modafinil, tell your doctor if you are taking any of the
following drugs:
· a monoamine oxidase inhibitor (MAO inhibitor) such as isocarboxazid
(Marplan), tranylcypromine (Parnate), or phenelzine (Nardil);
· a tricyclic antidepressant such as clomipramine (Anafranil) or desipramine
(Norpramin);
· another CNS stimulant such as amphetamine-dextroamphetamine (Adderall),
methylphenidate (Ritalin, Methylin, Metadate ER, Concerta), pemoline (Cylert),
and others;
· phenytoin (Dilantin);
· carbamazepine (Tegretol);
· phenobarbital;
· rifampin (Rifadin, Rimactane);
· ketoconazole (Nizoral);
· itraconazole (Sporanox);
· cyclosporine (Neoral, Sandimmune);
· theophylline (Theolair, Theochron, Theo-Bid, Theo-Dur, Elixophyllin,
Slo-Phyllin, and others);
· warfarin (Coumadin);
· diazepam (Valium); or
· propranolol (Inderal).
• You may not be able to take modafinil, or you may require a dosage adjustment
or special monitoring during your treatment if you are taking any of the medicines
listed above.
• Drugs other than those listed here may also interact with modafinil.
Talk to your doctor and pharmacist before taking or using any other prescription
or over-the-counter medicines, including vitamins, minerals, and herbal products.
